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The Influence of pH and Temperature on the Degradation Kinetics of 4-methoxy-2-[3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c] Pyridine in Aqueous Solutions

The Influence of pH and Temperature on the Degradation Kinetics of 4-methoxy-2-[3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c] Pyridine in Aqueous Solutions

Izabela Muszalska, Krzysztof Wituła

Acta Pol Pharm. Mar-Apr 2005;62(2):83-8.

PMID: 16161346

Abstract:

The pH-rate profiles for hydrolysis of 4-methoxy-2-[3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c] pyridine (H) at 333, 343, 353 and 363 K over the pH range 0.4-5.0 was investigated. The decomposition was followed by the HPLC method (LiChrosorb 100 RP-18 column 250 x 4.0 mm I.D., dp = 5 microm; mobile phase: acetonitrile-phosphate buffer (pH = 2; 0.01 mole/L) (45: 55, v/v or 30: 70, v/v). The pH-rate profile indicated specific acid- and base-catalysed reactions as well as spontaneous water-catalysed degradation of two molecules of II (as a dication and monocation). The ionic strength effect, the pKa value (2.4; 6.2), the pHmin value (2.1) and thermodynamic parameters of the reaction (energy and enthalpy of activation and the frequency coefficient for the specific rate constants) were determined.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP871126204	4-Methoxy-2,3,5,6-tetrafluorophenylboronic acid		871126-20-4	Price

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