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The Iridoid Glucoside Secologanin Is Derived From the Novel Triose phosphate/pyruvate Pathway in a Catharanthus Roseus Cell Culture

A Contin, R van der Heijden, A W Lefeber, R Verpoorte

FEBS Lett. 1998 Sep 4;434(3):413-6.

PMID: 9742965

Abstract:

Secologanin is the iridoid building block of the majority of the terpenoid indole alkaloids. In the biosynthesis of secologanin, mevalonate was considered to be the exclusive precursor of isopentenyl diphosphate. After [1-(13)C]glucose feeding to a cell culture of Catharanthus roseus, its incorporation into secologanin was studied by 13C NMR spectroscopy. The data showed that the novel triose phosphate/pyruvate and not the mevalonate pathway was the major route for the biosynthesis of secologanin.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP19351634 Secologanin Secologanin 19351-63-4 Price
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