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The JAK2/STAT3 Pathway Is Involved in the Anti-Melanoma Effects of Atractylenolide I

The JAK2/STAT3 Pathway Is Involved in the Anti-Melanoma Effects of Atractylenolide I

Xiu-Qiong Fu, Ji-Yao Chou, Ting Li, Pei-Li Zhu, Jun-Kui Li, Cheng-Le Yin, Tao Su, Hui Guo, Kin-Wah Lee, Muhammad Jahangir Hossen, Gui-Xin Chou, Zhi-Ling Yu

Exp Dermatol. 2018 Feb;27(2):201-204.

PMID: 29078004

Abstract:

In this study, we aimed to investigate the anti-melanoma effects and the JAK2/STAT3 pathway-related mechanism of action of atractylenolide I in human melanoma cells. Our results showed that atractylenolide I effectively reduced viability, induced apoptosis and inhibited migration of melanoma cells. Meanwhile, atractylenolide I decreased the protein expression levels of phospho-JAK2 and phospho-STAT3, and in turn downregulated the mRNA levels of STAT3-targeted genes, including Bcl-xL, MMP-2 and MMP-9. Furthermore, the cytotoxic effect of atractylenolide I was attenuated in STAT3-overactivated A375 cells. These findings indicate that inhibition of JAK2/STAT3 signalling contributes to the anti-melanoma effects of atractylenolide I.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP73069133	Atractylenolide I		73069-13-3	Price

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