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The Many Faces of Calmodulin in Cell Proliferation, Programmed Cell Death, Autophagy, and Cancer

The Many Faces of Calmodulin in Cell Proliferation, Programmed Cell Death, Autophagy, and Cancer

Martin W Berchtold, Antonio Villalobo

Biochim Biophys Acta. 2014 Feb;1843(2):398-435.

PMID: 24188867

Abstract:

Calmodulin (CaM) is a ubiquitous Ca(2+) receptor protein mediating a large number of signaling processes in all eukaryotic cells. CaM plays a central role in regulating a myriad of cellular functions via interaction with multiple target proteins. This review focuses on the action of CaM and CaM-dependent signaling systems in the control of vertebrate cell proliferation, programmed cell death and autophagy. The significance of CaM and interconnected CaM-regulated systems for the physiology of cancer cells including tumor stem cells, and processes required for tumor progression such as growth, tumor-associated angiogenesis and metastasis are highlighted. Furthermore, the potential targeting of CaM-dependent signaling processes for therapeutic use is discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP89108463-A	N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride		89108-46-3	Price

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