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The Metabolism of Dibenz[a,j]acridine in the Isolated Perfused Lung

The Metabolism of Dibenz[a,j]acridine in the Isolated Perfused Lung

D Warshawsky, L Hollingsworth, R Reilman, D Stong

Cancer Lett. 1985 Sep 30;28(3):317-26.

PMID: 4053001

Abstract:

The metabolism of the carcinogenic N-heterocyclic aromatic, dibenz[a,j]-acridine (DB[a,j]A), was investigated in an isolated perfused rabbit lung preparation. The rate of metabolism of DB[a,j]A was less than the rate of metabolism of 7H-dibenzo[c,g]carbazole (DB[c,g]C) in the untreated and corn oil-pretreated animals. A significantly increased rate of metabolism was observed for DB[a,j]A in benzo[a]pyrene(B[a]P)-pretreated animals. This resulted in marked increases in conjugation and distribution of conjugates and total metabolites in blood and lung. Two major metabolites characterized spectroscopically were assigned as the 3,4-dihydrodiol and a phenol of DB[a,j]A. The results indicate that in the lung DB[a,j]A is metabolized in a manner similar to that of B[a]P.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP224420	Dibenz(a,j)acridine		224-42-0	Price

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