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The Metabolism of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene and Gamma-Hexachlorocyclohexane in Rats

The Metabolism of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene and Gamma-Hexachlorocyclohexane in Rats

P L Grover, P Sims

Biochem J. 1965 Aug;96(2):521-5.

PMID: 4158352

Abstract:

1. After intraperitoneal administration, gamma-hexachlorocyclohexane (Gammexane) and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene were converted by rats into 2,3,5- and 2,4,5-trichlorophenol, which were excreted as free phenols and as sulphuric acid and glucuronic acid conjugates. 2. Derivatives of 2,4,5-trichlorophenol and 2,4,5-trichlorophenyl glucosiduronic acid and 2,4-dichlorophenylmercapturic acid were isolated from the urine as metabolites of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene. 3. The phenolic metabolites of gamma-hexachlorocyclohexane and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene isolated from urine were similar to those of 1,2,4-trichlorobenzene, which indicates that the two latter compounds are intermediates in gamma-hexachlorocyclohexane metabolism in rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP197223362	2,3,5,6-Tetramethylphenylboronic acid		197223-36-2	Price

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