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The Metabotropic Glutamate Receptor Antagonist (+)-alpha-methyl-4-carboxyphenylglycine Protects Hippocampal CA1 Neurons of the Rat From in Vitro hypoxia/hypoglycemia

The Metabotropic Glutamate Receptor Antagonist (+)-alpha-methyl-4-carboxyphenylglycine Protects Hippocampal CA1 Neurons of the Rat From in Vitro hypoxia/hypoglycemia

T Opitz, P Richter, K G Reymann

Neuropharmacology. 1994 May;33(5):715-7.

PMID: 7936108

Abstract:

The ability of the selective metabotropic glutamate receptor (mGluR) antagonist alpha-methyl-4-carboxyphenylglycine (MCPG) to protect hippocampal CA1 neurons from a hypoxic/hypoglycemic injury was examined. Rat hippocampal slices were exposed to a 4 min hypoxia/hypoglycemia, and the recovery of evoked population spikes was monitored. 500 microM (+)-MCPG exhibited a statistically significant protective effect, whereas the (-)-isomer was ineffective. These data suggest that MCPG-sensitive mGluRs may contribute to hypoxia/hypoglycemia-induced injury in rat hippocampal slices.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP150145894	(+)-α-Methyl-4-carboxyphenylglycine		150145-89-4	Price

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