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[The Natural Triterpenoid Miliacin Prevents Methotrexate-Induced Oxidative Stress and Normalizes the Expression of Genes Encoding the Cytochrome P-450 2E1 Isoform and Glutathione Reductase in the Liver]

[The Natural Triterpenoid Miliacin Prevents Methotrexate-Induced Oxidative Stress and Normalizes the Expression of Genes Encoding the Cytochrome P-450 2E1 Isoform and Glutathione Reductase in the Liver]

O V Kalinina, E S Kolotova, T V Panfilova, A A Shtil, B A Frolov

Patol Fiziol Eksp Ter. Jan-Mar 2013;(1):70-4.

PMID: 23805719

Abstract:

We studied the role of the natural triterpenoid miliacin (3-3-methoxy-Al8-oleanene) in the regulation of oxidative stress in the liver of (CBAxC57B1(6))F1 mice exposed to methotrexate. Miliacin attenuated methotrexate-induced lipid peroxidation as determined by an attenuation of thiobarbituric acid-reacting products in the liver. Furthermore, miliacin normalized the expression of genes encoding the 2e1 isoform of cytochrome P-450 and glutathione reductase that were dramatically dysregulated by methotrexate. These results established the role of miliacin in modulation of redox genes, thereby providing evidence for a new mechanism of organ protection by this triterpenoid.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5945459	Miliacin		5945-45-9	Price

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