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The Neuropharmacology of L-theanine(N-ethyl-L-glutamine): A Possible Neuroprotective and Cognitive Enhancing Agent

The Neuropharmacology of L-theanine(N-ethyl-L-glutamine): A Possible Neuroprotective and Cognitive Enhancing Agent

Pradeep J Nathan, Kristy Lu, M Gray, C Oliver

J Herb Pharmacother. 2006;6(2):21-30.

PMID: 17182482

Abstract:

L-theanine (N-ethyl-L-glutamine) or theanine is a major amino acid uniquely found in green tea. L-theanine has been historically reported as a relaxing agent, prompting scientific research on its pharmacology. Animal neurochemistry studies suggest that L-theanine increases brain serotonin, dopamine, GABA levels and has micromolar affinities for AMPA, Kainate and NMDA receptors. In addition has been shown to exert neuroprotective effects in animal models possibly through its antagonistic effects on group 1 metabotrophic glutamate receptors. Behavioural studies in animals suggest improvement in learning and memory. Overall, L-theanine displays a neuropharmacology suggestive of a possible neuroprotective and cognitive enhancing agent and warrants further investigation in animals and humans.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3081616-A	L-Theanine		3081-61-6	Price

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