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The Non-Proteinogenic Amino Acids L-methionine Sulfoximine and DL-phosphinothricin Activate mTOR

The Non-Proteinogenic Amino Acids L-methionine Sulfoximine and DL-phosphinothricin Activate mTOR

Saverio Tardito, Martina Chiu, Renata Franchi-Gazzola, Valeria Dall'Asta, Paola Comi, Ovidio Bussolati

Amino Acids. 2012 Jun;42(6):2507-12.

PMID: 21769496

Abstract:

L-Methionine sulfoximine (MSO) and DL-Phosphinothricin (PPT), two non-proteinogenic amino acids known as inhibitors of Glutamine Synthetase, cause a dose-dependent increase in the phosphorylation of the mTOR substrate S6 kinase 1. The effect is particularly evident in glutamine-depleted cells, where mTOR activity is very low, but is detectable for PPT also in the presence of glutamine. The stimulation of mTOR activity by either MSO or PPT is strongly synergized by essential amino acids. Thus, the non-proteinogenic amino acids MSO and PPT are mTOR activators.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP15985394	L-Methionine sulfoximine		15985-39-4	Price

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