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The Polymerization Kinetics, Oxidation-Responsiveness, and in Vitro Anticancer Efficacy of Poly(ester-Thioether)s

The Polymerization Kinetics, Oxidation-Responsiveness, and in Vitro Anticancer Efficacy of Poly(ester-Thioether)s

Furong Cheng, Ting Su, Kui Luo, Yuji Pu, Bin He

J Mater Chem B. 2019 Feb 14;7(6):1005-1016.

PMID: 32255105

Abstract:

Biodegradable and stimuli-responsive polymers have been widely explored due to their great potential in various biomedical applications. Here, biodegradable and oxidation-responsive poly(ester-thioether)s with different backbones were prepared by polymerization of dithiols and diacrylates. Two isomeric dithiol monomers, 2,3-dimercaptobutane (DMB) and 1,4-butanedithiol (BDT), were employed to synthesize poly(ester-thioether)s in the presence of 1,6-hexanediol diacrylate (HDA). The polymerization and oxidation kinetics of poly(ester-thioether)s were found to be controllable by tuning the polymer backbones, which were prepared using different monomers. The polymerization kinetics demonstrated that BDT showed a faster polymerization rate than DMB due to less steric hindrance. Poly(ester-thioether)s PHBD and PHDM, which were prepared from BDT and DMB with HDA, respectively, showed the fastest and slowest oxidation-responsiveness both in THF solution and in the form of polymer films. Finally, the potential application of poly(ester-thioether)s as drug vehicles for anticancer therapy was confirmed by using doxorubicin (DOX) as a model drug. The DOX-loaded micelle DOX/mPEG-PHBD showed much faster H2O2-responsive drug release and better anticancer efficacy in both MCF-7 and 4T1 cells due to the higher sensitivity of PHBD to H2O2.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1191088	1,4-Butanedithiol		1191-08-8	Price

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