Home
Resources
Publications
The Porcine Skin Associated T-cell Homing Chemokine CCL27: Molecular Cloning and mRNA Expression in Piglets Infected Experimentally With Staphylococcus Hyicus

The Porcine Skin Associated T-cell Homing Chemokine CCL27: Molecular Cloning and mRNA Expression in Piglets Infected Experimentally With Staphylococcus Hyicus

Christina K Johnsen, Annette N Jensen, Peter Ahrens, Lars Ole Andresen

Vet Immunol Immunopathol. 2003 Nov 15;96(1-2):13-8.

PMID: 14522130

Abstract:

CCL27 (also named CTACK, ALP, ILC and ESkine) is a CC chemokine primarily expressed by keratinocytes of the skin. The cognate receptor of CCL27 named CCR10 (GPR-2), is also expressed in skin-derived cells, and in addition by a subset of peripheral blood T-cells and in a variety of other tissues. In this paper, we report the cloning of porcine CCL27 cDNA and investigation of CCL27 mRNA expression in Staphylococcus hyicus infected piglets. At the protein level, 77 and 74% homology was found to human and mouse CCL27 sequences, respectively. The results of the expression analyses show that CCL27 mRNA is upregulated in the skin of infected piglets and to a lesser extent in piglets recovered from disease and without clinical signs of infection, indicating a role for CCL27 both during inflammation and after recovery from an infection.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413102	CTACK (CCL27) from mouse			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: