Home
Resources
Publications
The Protective Effects of Enalapril Maleate and Folic Acid Tablets Against Contrast-Induced Nephropathy in Diabetic Rats

The Protective Effects of Enalapril Maleate and Folic Acid Tablets Against Contrast-Induced Nephropathy in Diabetic Rats

Jiantong Hou, Gaoliang Yan, Bo Liu, Boqian Zhu, Yong Qiao, Dong Wang, Ruifeng Li, Erfei Luo, Chengchun Tang

Biomed Res Int. 2018 Feb 7;2018:4609750.

PMID: 29560361

Abstract:

Background:
Renal vasoconstriction, oxidative stress, endothelial dysfunction, and apoptosis are the major causes of contrast-induced nephropathy (CIN). The aim of this study was to evaluate the protective effects of enalapril maleate and folic acid tablets on CIN in diabetic rats.
Methods:
Thirty-two Sprague-Dawley rats were divided into four groups: CIN (C), CIN + enalapril maleate (CE), CIN + folic acid (CF), and CIN + enalapril maleate and folic acid tablets (CEF). CE, CF, and CEF rats were treated orally with enalapril maleate, folic acid, or enalapril maleate and folic acid tablets, respectively, for 5 days. CIN was induced in all groups followed by analyzed biochemical parameters, oxidative stress markers, endothelial dysfunction parameters, renal histopathology, and TUNEL staining.
Results:
Serum creatinine, blood urea nitrogen, and malondialdehyde levels were lower in the CEF group than in the C group. Homocysteine, superoxide dismutase, glutathione peroxidase, and nitric oxide levels were higher in the CEF group than in the C group. Histopathology scores and percentage of apoptotic kidney cells in the CEF group were significantly decreased compared with those in the C group.
Conclusions:
These results suggest that enalapril maleate and folic acid tablets have a protective effect against CIN in diabetic rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP76095164-B	Enalapril Maleate		76095-16-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: