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The PTEN Inhibitor bpV(pic) Promotes Neuroprotection Against Amyloid β-peptide (25-35)-induced Oxidative Stress and Neurotoxicity

The PTEN Inhibitor bpV(pic) Promotes Neuroprotection Against Amyloid β-peptide (25-35)-induced Oxidative Stress and Neurotoxicity

Xiao-Ying Liu, Li-Jing Zhang, Zhou Chen, Li-Bin Liu

Neurol Res. 2017 Aug;39(8):758-765.

PMID: 28436304

Abstract:

Objectives:
The aim of this study was to elucidate the mechanism underlying the neuroprotective effects of the phosphatase and tensin homolog (PTEN) inhibitor, bisperoxovanadium-pic [bpV(pic)].
Methods:
We determined the effects of bpV(pic) on amyloid-β-peptide-(25-35)-induced neurotoxicity, particularly intracellular reactive oxygen species (ROS) production and mitochondria-mediated apoptotic signaling, in a human neuroblastoma (SH-SY5Y) cell model.
Results:
We found that exposure of SH-SY5Y cells to amyloid β peptides (Aβ25-35) resulted in a significant reduction in cell viability accompanied by increased lactate dehydrogenase (LDH) release, elevated levels of intracellular ROS, and decreased superoxide dismutase (SOD) activities, all of which were reversed by co-treatment with bpV(pic). Moreover, bpV(pic) induced significant protection against Aβ25-35-induced apoptosis, and effectively suppressed mitochondria-dependent apoptotic signaling triggered by Aβ25-35.
Discussion:
Aβ peptides are thought to cause neurodegeneration in Alzheimer's disease (AD), via the induction of free radical oxidative stress. Our results indicate that bpV(pic) provides protection against Aβ25-35-induced oxidative stress and neurotoxicity, suggesting that bpV(pic) could be a potential therapeutic candidate in the treatment of neurodegenerative diseases such as AD.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP148556278	bpV(pic)		148556-27-8	Price

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