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The Release of ATP Triggered by Transmitter Action and Its Possible Physiological Significance: Retrograde Transmission

The Release of ATP Triggered by Transmitter Action and Its Possible Physiological Significance: Retrograde Transmission

M Israël, F M Meunier

J Physiol (Paris). 1978;74(5):485-90.

PMID: 217996

Abstract:

1. When a slice of electric organ of Torpedo is stimulated and superfused with a solution containing a firefly lantern extract, it is possible to measure the release of ATP after each nerve impulse as a light emission. 2. The postsynaptic action of released ACh induces the release of ATP by the postsynaptic cell. Most of the released ATP is of postsynaptic origin. 3. Ion fluxes associated with depolarization, or depolarization itself, trigger the release of ATP from postsynaptic and presynaptic membranes (synaptosomes). 4. ATP is able to block ACh release; a postsynaptic "retrograde transmission" able to control presynaptic transmitter release is possible.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR424787	Firefly Lantern Extract			Price

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