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The Return of the Nucleus: Transcriptional and Epigenetic Control of Autophagy

The Return of the Nucleus: Transcriptional and Epigenetic Control of Autophagy

Jens Füllgrabe, Daniel J Klionsky, Bertrand Joseph

Nat Rev Mol Cell Biol. 2014 Jan;15(1):65-74.

PMID: 24326622

Abstract:

Autophagy is a conserved process by which cytoplasmic components are degraded by the lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were not considered of primary importance for this process. However, recent studies have unveiled a transcriptional and epigenetic network that regulates autophagy. The identification of tightly controlled transcription factors (such as TFEB and ZKSCAN3), microRNAs and histone marks (especially acetylated Lys16 of histone 4 (H4K16ac) and dimethylated H3K9 (H3K9me2)) associated with the autophagic process offers an attractive conceptual framework to understand the short-term transcriptional response and potential long-term responses to autophagy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR424854	SOLu-Trypsin Dimethylated			Price

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