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The Role of Dopamine Receptors in Ventrolateral Orbital Cortex-Evoked Antinociception in a Rat Formalin Test Model

The Role of Dopamine Receptors in Ventrolateral Orbital Cortex-Evoked Antinociception in a Rat Formalin Test Model

Yong-Hui Dang, Bo Xing, Yan Zhao, Xin-Jie Zhao, Fu-Quan Huo, Jing-Shi Tang, Chao-Ling Qu, Teng Chen

Eur J Pharmacol. 2011 Apr 25;657(1-3):97-103.

PMID: 21316357

Abstract:

The present study examined the roles of dopamine and D(1)- and D(2)-like dopamine receptors in ventrolateral orbital cortex (VLO)-evoked antinociception in rats with persistent inflammatory pain. Following formalin injection into the rat unilateral hindpaw pad, the effects of dopamine receptor agonist and antagonist microinjections into the VLO on nociceptive behavior were observed. Results demonstrated that VLO microinjection of the non-selective dopamine receptor agonist apomorphine (R(-)-apomorphine hydrochloride, 1.0, 2.5 and 5.0μg) depressed later-phase nociceptive behavior induced by formalin injection; this effect was attenuated by the D(2)-like dopamine receptor antagonist S(-)-raclopride(+)-tartrate salt (raclopride, 3.0μg), but not by the D(1)-like dopamine receptor antagonist R(+)-SCH-23390 hydrochloride (SCH-23390, 1.0μg). Apomorphine-induced antinociception was mimicked by microinjection of the D(2)-like dopamine receptor agonist (-)-quinpirole hydrochloride (2.0 and 5.0μg) into the same VLO site, and this effect was antagonized by raclopride (3.0μg). In addition, microinjection of the D(1)-like dopamine receptor agonist R(+)-SKF-38393 hydrochloride (5.0μg) had no effect on formalin-induced nociceptive behavior during the later phase. However, the D(1)-like dopamine receptor antagonist SCH-23390 (2.5, 5.0 and 10μg) depressed nociceptive behavior in a dose-dependent manner. These results suggested that dopamine mediated VLO-induced antinociception via different mechanisms in the persistent inflammatory pain model; D(2)-like receptors mediated dopamine-induced antinociception, while D(1)-like dopamine receptors exhibited tonic facilitatory action on nociceptive behavior, thereby blocking D(1)-like dopamine receptors could induce antinociception.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP106648571	Nor-R-(+)-SCH-23390 hydrochloride	106648-57-1	Price
AP81702423	(R)-(+)-SKF-38393 hydrochloride	81702-42-3	Price
AP81702434	S-(−)-SKF-38393 hydrochloride	81702-43-4	Price

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