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The Role of Succinate in the Regulation of Intestinal Inflammation

The Role of Succinate in the Regulation of Intestinal Inflammation

Jessica Connors, Nick Dawe, Johan Van Limbergen

Nutrients. 2018 Dec 22;11(1):25.

PMID: 30583500

Abstract:

Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well as in patients with inflammatory bowel disease (IBD) and animal models of intestinal inflammation. Recent studies indicate that succinate can activate immune cells via its specific surface receptor, succinate receptor 1(SUCNR1), and enhance inflammation. However, the role of succinate in inflammatory processes within the gut mucosal immune system is unclear. This review includes current literature on the association of succinate with intestinal inflammation and the potential role of succinate⁻SUCNR1 signaling in gut immune functions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7411337	4arm-PEG40K-Succinimidyl Succinate			Price
LS7411393	8arm-PEG40K-Succinimidyl Succinate			Price

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