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The Role of the Adenosinergic System in Lung Fibrosis

The Role of the Adenosinergic System in Lung Fibrosis

Veronica Della Latta, Manuela Cabiati, Silvia Rocchiccioli, Silvia Del Ry, Maria-Aurora Morales

Pharmacol Res. 2013 Oct;76:182-9.

PMID: 23994158

Abstract:

Adenosine (ADO) is a retaliatory metabolite that is expressed in conditions of injury or stress. During these conditions ATP is released at the extracellular level and is metabolized to adenosine. For this reason, adenosine is defined as a "danger signal" for cells and organs, in addition to its important role as homeostatic regulator. Its physiological functions are mediated through interaction with four specific transmembrane receptors called ADORA1, ADORA2A, ADORA2B and ADORA3. In the lungs of mice and humans all four adenosine receptors are expressed with different roles, having pro- and anti-inflammatory roles, determining bronchoconstriction and regulating lung inflammation and airway remodeling. Adenosine receptors can also promote differentiation of lung fibroblasts into myofibroblasts, typical of the fibrotic event. This last function suggests a potential involvement of adenosine in the fibrotic lung disease processes, which are characterized by different degrees of inflammation and fibrosis. Idiopathic pulmonary fibrosis (IPF) is the pathology with the highest degree of fibrosis and is of unknown etiology and burdened by lack of effective treatments in humans.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP152918268	AB-MECA	152918-26-8	Price
AP212329378	MRS 1523	212329-37-8	Price
AP38594966	(−)-N6-(2-Phenylisopropyl)adenosine	38594-96-6	Price

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