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The Sensitivity of Axenic 200:NIH Entamoeba Histolytica to Bacitracin and Its Zinc Salt

The Sensitivity of Axenic 200:NIH Entamoeba Histolytica to Bacitracin and Its Zinc Salt

B J Andrews

Acta Trop. 1994 Jun;57(1):11-20.

PMID: 7942350

Abstract:

This study extends the previous knowledge of the action of bacitracin zinc against xenic cultures of Entamoeba histolytica. Results presented here, using axenic E. histolytica, confirm the enhanced activity of bacitracin zinc as compared to native bacitracin and demonstrate that this enhancement is due to a direct effect upon the trophozoite. In the presence of zinc, amoebastatic concentrations of bacitracin became amoebacidal. The expression of the amoebacidal characteristics of 5 g/l bacitracin zinc following 24-35 h incubation coincided with the return of cell division by amoeba exposed to the same concentration of native bacitracin. The activity of both bacitracin and bacitracin zinc on trophozoites was unaffected by autoclaving, indicating a mode of action different from that exerted on Staphylococcus aureus. In contrast to previous clinical observations, no synergism could be detected between bacitracin and neomycin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1405896-A	Bacitracin Zinc		1405-89-6	Price

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