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The synthesis of [1- 14 C]2-(1H-tetrazol-5-yl)acetic acid

The synthesis of [1- 14 C]2-(1H-tetrazol-5-yl)acetic acid

Brad D Maxwell, Scott B Tran

J Labelled Comp Radiopharm. 2017 Jan;60(1):49-54.

PMID: 27966233

Abstract:

Tetrazoles are a common heterocyclic functionality in many biologically active molecules. [1-14 C]2-(1H-Tetrazol-5-yl)acetic acid was required as an intermediate in the synthesis of a development candidate as part of a discovery phase program to complete metabolic profiling studies. [1-14 C]2-(1H-Tetrazol-5-yl)acetic acid was prepared in 4 steps overall and in 3 radiochemical steps from K14 CN in an overall 32% radiochemical yield.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23981477	2-(6-Methoxynaphthalen-2-yl)acetic acid		23981-47-7	Price

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