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The Synthesis of Weak Acidic Type Hybrid Monolith via Thiol-Ene Click Chemistry and Its Application in Hydrophilic Interaction Chromatography

The Synthesis of Weak Acidic Type Hybrid Monolith via Thiol-Ene Click Chemistry and Its Application in Hydrophilic Interaction Chromatography

Jiao Zeng, Shengquan Liu, Menglin Wang, Shouzhuo Yao, Yingzhuang Chen

Electrophoresis. 2017 May;38(9-10):1325-1333.

PMID: 28211065

Abstract:

In this work, a porous structure and good permeability monolithic column was polymerized in UV transparent fused-silica capillaries via photo-initiated thiol-ene click polymerization of 2,4,6,8-tetravinyl-2,4,6,8-tetramethylcyclotetrasiloxane (TMTVS), pentaerythritol tetra(3-mercaptopropionate)(PETMP), itaconic acid, respectively, in the presence of porogenic solvents (tetrahydrofuranand methanol) and an initiator (2,2-dimethoxy-2-phenylacetophenone) (DMPA) within 30 min. The physical properties of this monolith were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and nitrogen adsorption/desorption measurements. For an overall evaluation of the monolith in chromatographic application, separations of polycyclic aromatic hydrocarbons (PAHs), phenols, amides and bases were carried out. The column efficiency of this monolith could be as high as 112 560 N/m. It also possesses a potential application in fabrication of monoliths with high efficiency for c-LC. In addition, the resulting monolithic column demonstrated the potential use in analysis of environment waters.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2370889	2,4,6,8-Tetramethylcyclotetrasiloxane		2370-88-9	Price

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