Home
Resources
Publications
The Thyrotropin-Releasing Hormone-Like Peptides pGlu-Phe-Pro Amide and pGlu-Glu-Pro Amide Increase Plasma Triiodothyronine Levels in the Mouse; The Activity Is Sensitive to Testosterone

The Thyrotropin-Releasing Hormone-Like Peptides pGlu-Phe-Pro Amide and pGlu-Glu-Pro Amide Increase Plasma Triiodothyronine Levels in the Mouse; The Activity Is Sensitive to Testosterone

A Cremades, R Peñafiel, V Rausell, J Del Rio-Garcia, D G Smyth

Eur J Pharmacol. 1998 Sep 25;358(1):63-7.

PMID: 9809870

Abstract:

Three naturally occurring peptides, pGlu-Glu-Pro amide, pGlu-Phe-Pro amide and pGlu-Gln-Pro amide, with similar structures to thyrotropin releasing hormone (TRH) have recently been identified but no studies of their in vivo activities have been reported previously. We describe here the ability of pGlu-Phe-Pro amide and pGlu-Glu-Pro amide to influence thyroid status. Subcutaneous administration of these 'TRH-like' peptides in male and female CDI mice led to increased levels of triiodothyronine (T3) and to a lesser extent tetraiodothyronine (T4) in the circulation. pGlu-Phe-Pro amide was more potent than pGlu-Glu-Pro amide; it exhibited a similar potency to pGlu-His-Pro amide (TRH). pGlu-Phe-Pro amide, pGlu-Glu-Pro amide and TRH produced significantly greater effects in the female than in the male. Castration of male mice led to increased activities, with potencies comparable to those seen in the female; in contrast treatment of female mice with testosterone resulted in reduced activities, similar to those observed in the control male. The effects of potassium deprivation on the activities of the TRH-like peptides were also investigated. This diet, which results in decreased testosterone levels in the male, led to increased activities of the TRH-like peptides and TRH, approaching the potencies observed in the female. The results demonstrate that the TRH-like peptides pGlu-Phe-Pro amide and pGlu-Glu-Pro amide which occur naturally in the thyroid gland exhibit biological activity in influencing thyroid status in vivo. The activities are sensitive to testosterone.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP128340476	Lys-Ala-Arg-Val-Nle-p-nitro-Phe-Glu-Ala-Nle amide		128340-47-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: