0

The Total Synthesis of Roquefortine C and a Rationale for the Thermodynamic Stability of Isoroquefortine C Over Roquefortine C

Ning Shangguan, Warren J Hehre, William S Ohlinger, Mary Pat Beavers, Madeleine M Joullié

J Am Chem Soc. 2008 May 14;130(19):6281-7.

PMID: 18412344

Abstract:

The first total synthesis of roquefortine C is achieved by implementation of a novel elimination strategy to construct the thermodynamically unstable E-dehydrohistidine moiety. Molecular modeling studies are presented which explain the instability of the roquefortine C structure compared to that of isoroquefortine C.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP58735641 Roquefortine C Roquefortine C 58735-64-1 Price
qrcode