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Theaflavin-3, 3'-digallate Inhibits Ovarian Cancer Stem Cells via Suppressing Wnt/β-Catenin Signaling Pathway

Theaflavin-3, 3'-digallate Inhibits Ovarian Cancer Stem Cells via Suppressing Wnt/β-Catenin Signaling Pathway

Haibo Pan, Eunhye Kim, Gary O Rankin, Yon Rojanasakul, Youying Tu, Yi Charlie Chen

J Funct Foods. 2018 Nov;50:1-7.

PMID: 30984291

Abstract:

Recent evidence indicates that ovarian cancer stem cells (CSCs) are responsible for ovarian cancer recurrence and drug resistance, resulting in the low long-term survival rate of patients with advanced ovarian cancer. We aimed to study the inhibitory effect of theaflavin-3, 3'-digallate (TF3), a black tea polyphenol on ovarian CSCs. Here, we showed that TF3 inhibited the proliferation of A2780/CP70 and OVCAR3 tumorshpere cells by suppressing their cell viability and colony formation capacity. TF3 inhibited the tumorsphere formation capacity of A2780/CP70 and OVCAR3 CSCs in serum-free and non-adherent conditions. TF3 inhibited A2780/CP70 and OVCAR3 CSCs isolated from tumorspheres by decreasing their cell viability and upregulating the protein expression of caspase-3 and -7 in the cells. We also revealed that TF3 inhibited ovarian CSCs through Wnt/β-catenin signaling pathway. Our results suggested that TF3 could inhibit ovarian CSCs and might be a potential agent for eradicating ovarian cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP30462352	Theaflavin 3,3′-digallate		30462-35-2	Price

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