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Thermal Decomposition of Thonzonium Bromide

Thermal Decomposition of Thonzonium Bromide

L Chafetz, R C Greenough, J Frank

Pharm Res. 1986 Oct;3(5):298-301.

PMID: 24271714

Abstract:

Thonzonium bromide, a quaternary ammonium compound used as a surface active agent in a phenylephrine nasal solution, gave a gas chromatographic peak which was proportional in height and area to its concentration. Quaternary ammonium salts are nonvolatile and polar, thus the peak was attributed to a thermal decomposition product. It was identified as hexadecyldimethylamine by spectroscopic analysis and comparison with an authentic sample. A second product was identified by mass spectroscopy as 2[(2-hexadecylmethylaminoethyl)(4-methoxybenzylamino)] pyrimidine, the desmethyl bromide product. These decomposition products were detected in stability samples of formulations.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP553082	Thonzonium bromide		553-08-2	Price

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