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Thermally Gated Liposomes: A Closer Look

Thermally Gated Liposomes: A Closer Look

Ravil R Petrov, Wen-Hua Chen, Steven L Regen

Bioconjug Chem. 2009 May 20;20(5):1037-43.

PMID: 19374405

Abstract:

A homologous series of pore-forming amphiphiles (PFAs), derived from cholic acid, lysine, and spermine, have been used as "thermal gates" for releasing sucrose from liposomes made from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (sodium salt) [DPPG]. Binding measurements have established that these PFAs are fully bound to these liposomes in their gel state and that their transfer to fluid phase membranes is negligible. Release experiments have shown that thermal gating is sensitive to both the size and the concentration of the PFA that are used. Increases in the extent of release of sucrose with increasing temperature that have been found in the gel/fluid coexistence region indicate the existence of heterogeneity among the liposomes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1241726124	1,2-Dierucoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt		1241726-12-4	Price
AP200880428	1,2-Distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt		200880-42-8	Price

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