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Thermosensitive Hydrogels Based on Polypeptides for Localized and Sustained Delivery of Anticancer Drugs

Thermosensitive Hydrogels Based on Polypeptides for Localized and Sustained Delivery of Anticancer Drugs

Yilong Cheng, Chaoliang He, Jianxun Ding, Chunsheng Xiao, Xiuli Zhuang, Xuesi Chen

Biomaterials. 2013 Dec;34(38):10338-47.

PMID: 24095250

Abstract:

Thermosensitive hydrogels based on poly(γ-ethyl-L-glutamate)-poly(ethylene glycol)-poly(γ-ethyl-L-glutamate) triblock copolymers (PELG-PEG-PELG) were prepared for localized and sustained delivery of anticancer drugs. The polypeptide-based hydrogels showed much lower critical gelation concentration than the traditional polyester-based hydrogels. In vivo biocompatibility studies revealed that the in situ formed gels in the subcutaneous layer last for ≈ 21 days, and H&E staining study suggested acceptable biocompatibility of our materials in vivo. Then the hydrogels were tried as injectable implants to encapsulate antitumor drug, paclitaxel (PTX), to assess the in situ anti-tumoral activity using liver cancer xenograft model. The results demonstrated that the PTX-incorporated hydrogels could efficiently suppress the tumor growth, and did not result in obvious damage to normal organs. Therefore, the polypeptide-based thermosensitive hydrogels designed in the present study have great potential to serve as an effective platform for localized anti-cancer drug delivery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25189520	Poly(γ-ethyl-L-glutamate)		25189-52-0	Price

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