0

Thionation of Tryptanthrin, Rutaecarpine, and Related Molecules With a Reagent Prepared From P4S10 and Pyridine

Ngarita Kingi, Jan Bergman

J Org Chem. 2016 Sep 2;81(17):7711-6.

PMID: 27525546

Abstract:

Reaction of P4S10 in hot pyridine produces a crystalline solid which can be collected and used for thionations in other solvents such as acetonitrile and sulfolane. The biologically active natural products tryptanthrine, rutaecarpine, 7,8-dehydrorutaecarpine, and some related compounds have now been converted to thionated versions simply by heating the molecules with this thionating reagent in sulfolane (typically at 135 °C for 20 min) followed by a workup in water. No chromatography was necessary.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP13220570-A Tryptanthrine Tryptanthrine 13220-57-0 Price
qrcode