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Thiophene Congeners of Morpholine and Allylamine Type Antifungals--Syntheses and Biological Activities

F Bracher, T Papke

Pharmazie. 1995 Aug;50(8):525-7.

PMID: 7568314

Abstract:

A thiophene analogue 8 of the antifungal drug amorolfine (1) was prepared starting from the alcohol 5. In addition, congeners of naftifine, terbinafine and butenafine, in which the naphthalene ring is replaced by a branched thienylalkyl group, wee synthesized. Of the four drug analogues only compound 9, related to terbinafine, showed significant antifungal activity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP65473134 Terbinafine Related Compound A Terbinafine Related Compound A 65473-13-4 Price
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