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Thrombopoietin-induced CXC Chemokines, NAP-2 and PF4, Suppress Polyploidization and Proplatelet Formation During Megakaryocyte Maturation

Thrombopoietin-induced CXC Chemokines, NAP-2 and PF4, Suppress Polyploidization and Proplatelet Formation During Megakaryocyte Maturation

Masaaki Oda, Yasuhiro Kurasawa, Kazuo Todokoro, Yuka Nagata

Genes Cells. 2003 Jan;8(1):9-15.

PMID: 12558795

Abstract:

Background:
We previously reported that the expressions of two CXC chemokines, neutrophil activating peptide-2 (NAP-2) and platelet factor-4 (PF-4), were induced by megakaryocyte-specific cytokine thrombopoietin (TPO) in mouse bone marrow megakaryocytes. The roles of these chemokines on megakaryocyte maturation/differentiation processes, including polyploidization and proplatelet formation (PPF) remain unresolved.
Results:
NAP-2 and PF-4 suppressed the PPF of mature megakaryocytes freshly prepared from mouse bone marrow as well as that of the megakaryocyte progenitors, c-Kit+CD41+ cells, isolated from mouse bone marrow and cultured with TPO. NAP-2 and PF-4 inhibited polyploidization of c-Kit+CD41+ cells in the presence of TPO, and also inhibited the proliferation of c-Kit+CD41+ cells.
Conclusions:
NAP-2 and PF-4 produced by TPO stimulation in megakaryocytes suppress megakaryocyte maturation and proliferation as a feedback control.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413114	PF-4 from mouse			Price

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