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Tip110 Maintains Expression of Pluripotent Factors in and Pluripotency of Human Embryonic Stem Cells

Tip110 Maintains Expression of Pluripotent Factors in and Pluripotency of Human Embryonic Stem Cells

Ying Liu, Man-Ryul Lee, Khalid Timani, Johnny J He, Hal E Broxmeyer

Stem Cells Dev. 2012 Apr 10;21(6):829-33.

PMID: 22132941

Abstract:

HIV-1 Tat-interacting protein of 110 kDa [Tip110; p110(nrb)/SART3/p110] is an RNA binding nuclear protein implicated in regulation of HIV-1 gene and host gene transcription, pre-mRNA splicing, and cancer immunology. Recently, we demonstrated a role for Tip110 in regulation of hematopoiesis. Here, we show that TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs. TIP110 was found, through up- and down-modulation of expression of Tip110, to be important in maintaining pluripotent factor (NANOG, OCT4, and SOX2) expression in and pluripotency of hESCs, although the mechanisms involved and whether the Tip110 effects are direct remain to be determined.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4246383	NANOG TAT human			Price

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