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Tissue Distribution and Deposition of Clofazimine in Rat Following Subchronic Treatment With or Without Rifampicin

Tissue Distribution and Deposition of Clofazimine in Rat Following Subchronic Treatment With or Without Rifampicin

N V Mamidi, A Rajasekhar, M C Prabhakar, D R Krishna

Arzneimittelforschung. 1995 Sep;45(9):1029-31.

PMID: 7488306

Abstract:

Tissue distribution and deposition characteristics of clofazimine (CAS 2030-63-9), an antileprotic drug in rats have been investigated following controlled sub-chronic administration (p.o.) for a period of 1-2 months. The drug was administered alone at a dose of 20 mg/kg body weight and in combination with rifampicin (CAS 13292-46-1) (20 mg/kg p.o.). Various tissues (liver, lung, spleen, small intestine, brain, heart, kidney, skin, stomach and subcutaneous fat) were analyzed for clofazimine in all the treated groups. High levels (range 0.9-3.6 mg/g of wet tissue) were observed in tissues having reticuloendothelial components. In other tissues the levels were relatively lower (range 3-114 micrograms/g of wet tissue). Histopathological studies revealed that clofazimine is deposited in many tissues in the form of reddish-orange crystals. Concomitant treatment with rifampicin did not significantly alter tissue distribution or deposition profile of clofazimine nor did it influence the histopathology.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13292461-A	Rifampicin - CAS 13292-46-1		13292-46-1	Price

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