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Tofogliflozin Salt Cocrystals With Sodium Acetate and Potassium Acetate

Tofogliflozin Salt Cocrystals With Sodium Acetate and Potassium Acetate

Noriyuki Takata, Satoshi Tanida, Shinichi Nakae, Koji Shiraki, Yuichi Tozuka, Masaki Ishigai

Chem Pharm Bull (Tokyo). 2018;66(11):1035-1040.

PMID: 30381655

Abstract:

We investigated the salt cocrystals formed by tofogliflozin with sodium acetate and potassium acetate by determining the crystal structures of the salt cocrystals and characterizing the solid states. The salt cocrystal screening using the slurry method and the liquid-assisted grinding method resulted in the formation of tofogliflozin-sodium acetate 1 : 1 and tofogliflozin-potassium acetate 1 : 1 salt cocrystals. Single-crystal X-ray diffraction revealed that, although each salt cocrystal belongs to a different space group, both of the salt cocrystals have almost similar structural features, including the conformation of tofogliflozin molecules, the coordination to Na+/K+ ions, and hydrogen bonds. The salt cocrystals exhibited extreme hygroscopicity with deliquescence, which is also a property of sodium acetate and potassium acetate. In addition, tofogliflozin-potassium acetate salt cocrystal had two polymorphs, which were enantiotropically related.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP127082-B	Potassium acetate		127-08-2	Price
AP127093-B	Sodium acetate		127-09-3	Price

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