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Topical Timolol Promotes Healing of Chronic Leg Ulcer

Topical Timolol Promotes Healing of Chronic Leg Ulcer

Bindhiya Thomas, John Sajan Kurien, Toney Jose, Sansho Elavumkal Ulahannan, Sandeep Abraham Varghese

J Vasc Surg Venous Lymphat Disord. 2017 Nov;5(6):844-850.

PMID: 29037357

Abstract:

Background:
Chronic ulcers are a common problem, with chronic diabetic and venous ulcers forming a large proportion. This is the first case-control study to assess the effect of topical timolol on healing of chronic venous and chronic diabetic ulcers.
Methods:
The study included 60 patients with chronic leg ulcers. The ulcers in the study group (n = 30) were treated with topical 0.5% timolol maleate solution along with antibiotics and dressings; those in the control group (n = 30) received only antibiotics and dressings. The ulcers in both groups were evaluated at 4, 8, and 12 weeks, and ulcer area was calculated. Healing rate was assessed by calculating the percentage change in ulcer area.
Results:
The mean percentage change in area at 4, 8, and 12 weeks was 25.29, 43.77, and 61.79 in the study group and 11.92, 22.40, and 29.62 in the control group. Analysis showed that there were significant differences in percentage change in ulcer of the study and control groups at all three time points and also within the groups. The type of ulcer, history of alcohol consumption, and smoking did not affect the healing rates in the study group.
Conclusions:
Topical β-blockade using timolol improves the healing of chronic leg ulcers.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1219806457	Chlorpheniramine-D6 maleate solution		1219806-45-7	Price
AP136765474	(±)-Norpropoxyphene-d5 maleate solution		136765-47-4	Price

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