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Topiramate in Benzodiazepine Withdrawal

Michel Cheseaux, Martine Monnat, Daniele F Zullino

Hum Psychopharmacol. 2003 Jul;18(5):375-7.

PMID: 12858324

Abstract:

There is an increasing interest in anticonvulsants for the treatment of benzodiazepine withdrawal symptoms. The new anticonvulsant compound topiramate seems to be an especially promising drug for this indication. It acts, among others, as an AMPA antagonist, which may be responsible in part for its anticonvulsant efficacy, but may also modulate the withdrawal-induced activation of noradrenergic neurons in the locus coeruleus, which are related to some behavioural effects of benzodiazepine withdrawal. A case is presented of a rapid benzodiazepine-withdrawal treated successfully with topiramate.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP20880926 Topiramate Related Compound A Topiramate Related Compound A 20880-92-6 Price
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