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Total Synthesis of Bryostatin 3

Total Synthesis of Bryostatin 3

Barry M Trost, Youliang Wang, Andreas K Buckl, Zhongxing Huang, Minh H Nguyen, Olesya Kuzmina

Science. 2020 May 29;368(6494):1007-1011.

PMID: 32467391

Abstract:

Bryostatins are a family of 21 complex marine natural products with a wide range of potent biological activities. Among all the 21 bryostatins, bryostatin 3 is structurally the most complex. Whereas nine total syntheses of bryostatins have been achieved to date, bryostatin 3 has only been targeted once and required the highest number of steps to synthesize (43 steps in the longest linear sequence and 88 total steps). Here, we report a concise total synthesis of bryostatin 3 using 22 steps in the longest linear sequence and 31 total steps through a highly convergent synthetic plan by the use of highly atom-economical and chemoselective transformations in which alkynes played a major role in reducing step count.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP143370847	Bryostatin 3		143370-84-7	Price

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