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Total Synthesis of Lycopalhine A

Yuji Ochi, Satoshi Yokoshima, Tohru Fukuyama

Org Lett. 2016 Mar 18;18(6):1494-6.

PMID: 26950761

Abstract:

The total synthesis of lycopalhine A has been accomplished. The synthesis features construction of the tricyclic system via cleavage of a cyclopropane ring and an ensuing intramolecular Michael addition, stereoselective introduction of a 2-aminoethyl moiety via a reaction of allyltrimethylsilane to a sulfonyliminium ion, and a stereoselective intramolecular aldol reaction.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP762721 Allyltrimethylsilane Allyltrimethylsilane 762-72-1 Price
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