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Total Synthesis of Mangiferin, Homomangiferin, and Neomangiferin

Xiong Wei, Danlin Liang, Qing Wang, Xiangbao Meng, Zhongjun Li

Org Biomol Chem. 2016 Sep 21;14(37):8821-8831.

PMID: 27714296

Abstract:

Total synthesis of mangiferin, homomangiferin, and neomangiferin, three C-glycosyl xanthone natural products with a wide spectrum of pharmacological effects, has been achieved starting from 2,3,4,6-tetra-O-benzyl-α/β-d-glucopyranose. The key steps involve a stereoselective Lewis acid promoted C-glycosylation of protected phloroglucinol with tetrabenzylglucopyranosyl acetate and a highly regioselective base-induced cyclization for the construction of the core xanthone skeleton.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP64809672 Neomangiferin Neomangiferin 64809-67-2 Price
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