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Total Synthesis of the Natural Product EBC-329

Raju S Thombal, Vrushali H Jadhav

Org Biomol Chem. 2015 Sep 28;13(36):9485-91.

PMID: 26256620

Abstract:

The first total synthesis of an anti-leukemic diterpene natural product EBC-329 (1) has been accomplished starting from readily available 6,6-dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione (7). An efficient and general approach has been reported for the synthesis of EBC-329 in 13 steps with an overall yield of 10%.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP5617743 3-Oxabicyclo[3.1.0]hexane-2,4-dione 3-Oxabicyclo[3.1.0]hexane-2,4-dione 5617-74-3 Price
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