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Toxicity Studies of Tetradecanoic Acid, 2-sulfo-, 1-methylester, Sodium Salt (C14-MES)

Toxicity Studies of Tetradecanoic Acid, 2-sulfo-, 1-methylester, Sodium Salt (C14-MES)

Jun Sato, Yasuhito Yamamoto, Tsuneaki Nakamura, Shigeru Ishida, Yutaka Takagi

J Toxicol Sci. 2005 Dec;30(4):339-47.

PMID: 16404142

Abstract:

We evaluated the toxicity of tetradecanoic acid methyl ester sodium salt (C14-MES), a major component of fabric detergents, following the test guidelines of the Organization for Economic Cooperation and Development. The rat acute oral LD(50) was 1,000 mg/kg in males and 500 mg/kg in females. Applying the combined repeated dose and reproductive/developmental toxicity screening test (ReproTox), we exposed groups of Crj:CD (SD) IGS rats to C14-MES in the diet at concentrations of 0, 0.3, 0.6, or 1.2%. We observed decreases in fibrinogen levels and longer prothrombin time at the 1.2% treated level in females and decreases in serum triglyceride levels in both sexes at the 0.6% and 1.2% treatment levels, but the effects were not clinically significant. The no-observed-effect-level (NOEL) for repeated dose toxicity was 0.3% (175 mg/kg body weight/day for males, 249 for females). The NOEL for reproduction/developmental toxicity was 1.2% (740 mg/kg for males, 1039 for females). C14-MES was negative in the reverse gene mutation assay and the chromosomal aberration test and did not induce skin sensitization in the guinea pig maximization test. These data confirm that C14-MES is of low hazard potential.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP73548693	1,2-Dilauroyl-sn-glycero-3-phosphorylglycerol sodium salt		73548-69-3	Price

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