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[Toxicological Characteristics and Standardization of Various Poly-Metallic Oxides]

[Toxicological Characteristics and Standardization of Various Poly-Metallic Oxides]

E M Neizvestnova, B A Katsnel'son, V I Davydova, L G Malysheva, N E Konovalova

Gig Tr Prof Zabol. 1992;(6):23-6.

PMID: 1478519

Abstract:

Acute toxicity, functional cumulative and local effects of the four ++poly-metallic oxides YBa2Cu3O7, Bi4Sr3O16, Tl2Ca2Cu3O10, Lao,7Sro,3CoO3, were studied in laboratory animals. Parallel experiments on assessment toxicity of the regular oxides of the studied metals in mice were carried out. The major dissolution of metals was shown to occur in acid medium. Thallium-barium-calcium cuprite turned out to be the most toxic and cumulative; it induced the most severe morphologic changes in the liver and kidneys. The least severe disorders caused by this substance were in the rat gastric mucosa and in rabbit eye after a conjunctival injection. Yttrium-barium cuprite induced the most severe changes at the site of injection, lanthanum-strontium cobaltite ranks second here. All copper-containing polymetallic oxides show resorptive toxicity when applied to the skin. Different types of combined toxicity are possible, that is why MACs for the regular oxides can not be used for setting the normal concentrations of ++poly-metallic oxides in air. Estimated toxicometric parameters helped to score the concentrations, which may serve as tentative safe levels of the studies substances.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP108916092	Lanthanum strontium cobaltite, LSC-82		108916-09-2	Price

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