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Trace Quantification of 1-triacontanol in Beagle Plasma by GC-MS/MS and Its Application to a Pharmacokinetic Study

Trace Quantification of 1-triacontanol in Beagle Plasma by GC-MS/MS and Its Application to a Pharmacokinetic Study

Chunfeng Wang, Ali Fan, Xiaojie Zhu, Yang Lu, Shuhua Deng, Wenchao Gao, Wei Zhang, Qi Liu, Xijing Chen

Biomed Chromatogr. 2015 May;29(5):749-55.

PMID: 25331188

Abstract:

1-Triacontanol (TA), a member of long chain fatty alcohol, has recently been received great attention owing to its antitumor activity. In this study, an accurate, sensitive and selective gas chromatography-tandem mass spectrometry method was developed and validated for the quantification of TA in beagle plasma using 1-octacosanal as the internal standard (IS) for the first time. With temperature programming, chromatographic separation was carried out on an HP-5MS column, using helium as carrier gas and argon as collision gas, both at a flow rate of 1 mL/min. TA was analyzed using positive ion electrospray ionization in multiple-reaction monitoring mode, with the precursor to product ion transitions of m/z 495.6 → 97.0 and m/z 467.5 → 97.0 for TA and the IS, respectively. The lower limit of quantitation, linearity, intra- and interday precision, accuracy, stability, extraction recovery and matrix effect of TA were within the acceptable limits. The validated method was successfully applied to a pharmacokinetic study of TA in beagles.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP593500	1-Triacontanol		593-50-0	Price

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