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Tracking Antitumor Metallodrugs: Promising Agents With the Ru(II)- And Fe(II)-cyclopentadienyl Scaffolds

Tracking Antitumor Metallodrugs: Promising Agents With the Ru(II)- And Fe(II)-cyclopentadienyl Scaffolds

Tânia S Morais, Andreia Valente, Ana Isabel Tomaz, Fernanda Marques, Maria Helena Garcia

Future Med Chem. 2016 Apr;8(5):527-44.

PMID: 27096164

Abstract:

Research on the field of metal complexes for the treatment of cancer diseases has attracted increasing interest due to the urgency in finding more efficient and selective treatments. Owing to their wide structural diversity, organometallic complexes appear as potential alternatives to the design of new anticancer candidates. Herein, we review recent progress in our work toward the development of new drugs based on Ru(II)- and Fe(II)-cyclopentadienyl scaffolds. Their design and chemical properties are reviewed and correlated with their biological effects, in particular the key role that coligands play in the overall behavior of the complex.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1287134	Bis(cyclopentadienyl)ruthenium(II)		1287-13-4	Price

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