Home
Resources
Publications
Trans-3,5-dicaffeoylquinic Acid From Geigeria Alata Benth. & Hook.f. Ex Oliv. & Hiern With Beneficial Effects on Experimental Diabetes in Animal Model of Essential Hypertension

Trans-3,5-dicaffeoylquinic Acid From Geigeria Alata Benth. & Hook.f. Ex Oliv. & Hiern With Beneficial Effects on Experimental Diabetes in Animal Model of Essential Hypertension

Rumyana Simeonova, Vessela Vitcheva, Dimitrina Zheleva-Dimitrova, Vessela Balabanova, Ionko Savov, Sakina Yagi, Bozhana Dimitrova, Yulian Voynikov, Reneta Gevrenova

Food Chem Toxicol. 2019 Oct;132:110678.

PMID: 31323233

Abstract:

Geigeria alata Benth. & Hook.f. ex Oliv. & Hiern (Asteraceae) is used in Sudanese folk medicine for treatment of diabetes. The study aimed to estimate the acute oral toxicity of trans-3,5-dicaffeoylquinic acid (3,5-diCQA) from G. alata roots and to assess its antihypeglycemic, antioxidant and antihypertensive effects on chemically-induced diabetic spontaneously hypertensive rats (SHRs). The structure of 3,5-diCQA was established by NMR and HRMS spectra. Type 2 diabetes was induced by intraperitoneal injection of streptozotocin. 3,5-diCQA was slightly toxic with LD50 = 2154 mg/kg. At 5 mg/kg 3,5-diCQA reduced significantly (p < 0.05) the blood glucose levels by 42%, decreased the blood pressure by 22% and ameliorated the oxidative stress biomarkers reduced glutathione, malondialdehyde, and serum biochemical parameters. The beneficial effect on antioxidant enzymes was evidenced by the elevated glutathione peroxidase, glutathione reductase, and glutathione S-transferase activitiy in the livers of diabetic animals. 3,5-diCQA prevents the histopathological changes related to diabetes and hypertension. 3,5-diCQA was more potent α-glucosidase inhibitor (IC50 27.24 μg/mL) than acarbose (IC50 99.77 μg/mL). The antihyperglycemic action of the compound was attributed to the α-glucosidase inhibition. The beneficial effects of 3,5-diCQA on streptozotocin-induced diabetic hypertensive rats support the traditional use of G.alata for the management of diabetes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2450535	3,5-Dicaffeoylquinic acid		2450-53-5	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: