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Trans-4-hydroxy-3-methoxycinnamic Acid (Ferulic Acid) Inhibits the Effect of Androgens on the Rat Prostate

T Saito, T Nohno, H Yoshida, H Yokoya

Experientia. 1979 May 15;35(5):696-9.

PMID: 446686

Abstract:

Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) antagonized the effect of exogenous androgens on the ventral prostate (VP) in castrated rats as well as the effect of endogenous androgens in intact rats. FA, however, had no effect on the seminal vesicles (SV) and levator ani muscle (LAM), nor oestrogenic effect in female rats and mice. FA did not antagonize the receptor binding of testosterone nor inhibit the conversion of testosterone into 5 alpha-dihydrotestosterone (DHT).

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1135246-A 4-Hydroxy-3-methoxycinnamic acid 4-Hydroxy-3-methoxycinnamic acid 1135-24-6 Price
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