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Transcriptome Profiling and Pathway Analysis of Hepatotoxicity Induced by Tris (2-ethylhexyl) Trimellitate (TOTM) in Mice

Transcriptome Profiling and Pathway Analysis of Hepatotoxicity Induced by Tris (2-ethylhexyl) Trimellitate (TOTM) in Mice

Xian-Hua Chen, Li Ma, Yi-Xiang Hu, Dan-Xian Wang, Li Fang, Xue-Lai Li, Jin-Chuan Zhao, Hai-Rong Yu, Hua-Zhong Ying, Chen-Huan Yu

Environ Toxicol Pharmacol. 2016 Jan;41:62-71.

PMID: 26650799

Abstract:

Tris (2-ethylhexyl) trimellitate (TOTM) is commonly used as an alternative plasticizer for medical devices. But very little information was available on its biological effects. In this study, we investigated toxicity effects of TOTM on hepatic differential gene expression analyzed by using high-throughput sequencing analysis for over-represented functions and phenotypically anchored to complementary histopathologic, and biochemical data in the liver of mice. Among 1668 candidate genes, 694 genes were up-regulated and 974 genes were down-regulated after TOTM exposure. Using Gene Ontology analysis, TOTM affected three processes: the cell cycle, metabolic process and oxidative activity. Furthermore, 11 key genes involved in the above processes were validated by real time PCR. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that these genes were involved in the cell cycle pathway, lipid metabolism and oxidative process. It revealed the transcriptome gene expression response to TOTM exposure in mouse, and these data could contribute to provide a clearer understanding of the molecular mechanisms of TOTM-induced hepatotoxicity in human.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3319311	Tris(2-ethylhexyl) trimellitate		3319-31-1	Price

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