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Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue

Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue

Paul Petrus, Niklas Mejhert, Patricia Corrales, Simon Lecoutre, Qian Li, Estela Maldonado, Agne Kulyté, Yamila Lopez, Mark Campbell, Juan R Acosta, Jurga Laurencikiene, Iyadh Douagi, Hui Gao, Concepción Martínez-Álvarez, etc.

Cell Rep. 2018 Oct 16;25(3):551-560.e5.

PMID: 30332637

Abstract:

White adipose tissue (WAT) mass is determined by adipocyte size and number. While adipocytes are continuously turned over, the mechanisms controlling fat cell number in WAT upon weight changes are unclear. Herein, prospective studies of human subcutaneous WAT demonstrate that weight gain increases both adipocyte size and number, but the latter remains unaltered after weight loss. Transcriptome analyses associate changes in adipocyte number with the expression of 79 genes. This gene set is enriched for growth factors, out of which one, transforming growth factor-β3 (TGFβ3), stimulates adipocyte progenitor proliferation, resulting in a higher number of cells undergoing differentiation in vitro. The relevance of these observations was corroborated in vivo where Tgfb3+/- mice, in comparison with wild-type littermates, display lower subcutaneous adipocyte progenitor proliferation, WAT hypertrophy, and glucose intolerance. TGFβ3 is therefore a regulator of subcutaneous adipocyte number and may link WAT morphology to glucose metabolism.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248690	Transforming Growth Factor-β3 human			Price

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