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Transmembrane Signaling via Both CD3 and CD2 Human T Cell Surface Molecules Involves Protein kinase-C Translocation

Transmembrane Signaling via Both CD3 and CD2 Human T Cell Surface Molecules Involves Protein kinase-C Translocation

M Bagnasco, J Nunes, M Lopez, C Lipcey, C Mawas, D Olive

Ric Clin Lab. Jul-Sep 1989;19(3):221-9.

PMID: 2574494

Abstract:

The activation of T lymphocytes by appropriate pairs of anti-CD2 monoclonal antibodies has been shown to involve phospholipase-C and phosphoinositide hydrolysis. In this paper we show that the stimulation of the human cloned leukemic T cell line Jurkat by anti-CD2 as well as anti-CD3 monoclonal antibodies induces translocation from cytosol to cell membrane of protein kinase-C (PKC), which is dependent on the formation of 1,2-diacylglycerol from inositol 4,5-diphosphate. PKC translocation is rapid and transient: the kinetics of enzyme redistribution are similar for CD2 and CD3. These results further stress that CD2 and CD3 T cell activation pathways use similar signal transducing mechanisms.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248410	CD2 human			Price

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