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Transport Characteristics of Asymmetric Cellulose Triacetate Hemodialysis Membranes

Transport Characteristics of Asymmetric Cellulose Triacetate Hemodialysis Membranes

Tae Ryung Kim, Mahsa Hadidi, Seyed Pouria Motevalian, Takashi Sunohara, Andrew L Zydney

Blood Purif. 2018;45(1-3):46-52.

PMID: 29161718

Abstract:

Aims:
The objective of this study was to compare the transport characteristics of highly asymmetric cellulose triacetate (ATA™) membranes with that of both symmetric cellulose triacetate and asymmetric polysulfone membranes.
Methods:
Data were obtained for solute clearance and sieving coefficients of vitamin B12 and a range of polydisperse dextrans using ATA™ SOLACEA-25H and Optiflux F250NR polysulfone dialyzers. Results for these, and the CT190 symmetric cellulose triacetate dialyzer, were analyzed using available membrane transport models.
Results:
The ATA™ had the largest solute clearance, although the homogeneous CT190 dialyzer had the highest sieving coefficients. These differences were a direct result of the differences in the underlying membrane morphology, with the asymmetric ATA™ membrane providing much higher diffusive transport rates (and thus higher solute clearance).
Conclusions:
These results demonstrate the importance of membrane morphology on dialyzer transport and provide important insights into the effective clinical performance observed with the highly asymmetric ATA™ dialyzers.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9012093	Cellulose triacetate		9012-09-3	Price

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